Glaber Heterocephalus | Alamy
Species of mice without fur or naked mole or Heterocephalus Glaber has long been an attraction for researchers due to the ability of a long life. Glaber Heterocephalus viability could reach 30 years, this means 10 times longer than mice in general.
Currently the naked mole-rat (Heterocephalus Glaber) return attention because of chemical compounds that are known to have made these mice immune to cancer. This information is presented by a study led by Andrei Seluanov along with Vera Gorbunova from University Of Rochester.
Team researchers with research malakukan mengulturkan / tissue culturing cells in media in mice Heterocephalus Glaber who was rich in hyaluronan (HMW-HA) is a type of complex sugar that it also serves as a lubricant.
Because it contains hyaluronan hence these mice have the ability elasticity of the skin is hairless mice. Thus helps in moving agile in their habitat, and slipped in the hallway or the cavity underground cavity.
But research conducted when the compound hyaluronan (HMW-HA) eliminated the rats turned out to be susceptible to cancer. This fact indicates that the compound has the function of HMW-HA provides immunity against cancer.
The results provide new hope for therapeutic mechanisms of cancer prevention and treatment. It is, as expressed by Gorbunova on the BBC on Wednesday, 19-06-2013.
Expected to be further research related to the use of HMW-HA test in mice and human cells. Although the exact same version of the compound used in humans to address aging and inflammation of the joints (arthritis).
Seluanov also said that "There is no direct evidence that HMW-HA could work in humans. Compound is already used for the injection of anti-aging and overcome the pain caused by inflammation in the knee joint with no adverse effects. We hope it can also serve as an anti- cancer, "
But there are disadvantages of the use of HMW-HA which although has been proven to provide anti-cancer properties, application in humans will be difficult because all human cells must be manipulated to be able to express HMW-HA. Manipulation of these cells in humans are dangerous. The statement was published in the New Scientist on Wednesday, 19-06-2013.
According to Chris who was also involved in the research said that the substance HMW-HA can be useful in patients with rheumatoid arthritis. It is conceivable that in order to alleviate the symptoms of the disease and to be able to express HMW-HA cell engineering it is necessary to joint arthritis patients .. Chris is a researcher of the Harvard School of Public Health.
Substance hyaluronan (HMW-HA) may also be used to modify the skin cells, brain and human blood vessels.Since the production of hyaluronan (HMW-HA) at cells in these organs decreases with age. Scientists can manipulate the cells to produce HMW-HA in order to prevent aging.
Sources:
BBC, New Scientist
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